The Anti-Inflammatory Effect of Omega-7 Against Cisplatin in Rat Model
نویسندگان
چکیده

 Omega-7 (palmitoleic acid, 16:1 n7) is a monounsaturated fatty acid that found to have several beneficial effects. Cisplatin commonly considered for the treatment of different carcinomas. therapy restricted due its nephrotoxicity. Nephrotoxicity caused by cisplatin thought be associated with inflammatory reactions among other mechanisms. The aim present study was evaluate possible anti-inflammatory effect omega-7 on in rats. Thirty adult male Wistar Albino rats were divided randomly into five equal groups, group 1 received liquid paraffin solution orally 7 consecutive days, 2 (7.5 mg/kg) single intraperitoneal injection, 3 (50 oral administration days consecutively and then followed injection eighth day, 4 (100 5 only days. On day 9, all animals euthanized serum samples utilized assessment tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10) interleukin-1β (IL-1β). Treatment had led significant decline activities pro-inflammatory cytokines TNF-α IL-1β, reduction level IL-10. has an against adverse effects.
منابع مشابه
Anti-inflammatory and anti-apoptotic effects of hyperbaric oxygen preconditioning in a rat model of cisplatin-induced peripheral neuropathy
Objective(s): Cisplatin-induced peripheral neuropathy is a debilitating side effect in patients receiving this drug. Recent studies suggest hyperbaric oxygen (HBO) therapy as a new treatment approach for models of neural injury. The aim of the current study was to determine the protective effects of HBO preconditioning against peripheral neuropathy induced by Cisplati...
متن کاملThe anti-inflammatory effects of venlafaxine in the rat model of carrageenan-induced paw edema
Objective(s):Recently anti-inflammatory effects of antidepressants have been demonstrated. Venlafaxine belongs to newer antidepressants with serotonin norepinephrine reuptake inhibition property. The pain alleviating properties of venlafaxine in different pain models such as neurogenic pain, diabetic neuropathy, and fibromyalgia have been demonstrated. Anti-inflammatory effects of venlafaxine a...
متن کاملthe effect of the record infancy in crimilly acts of guilties (in karaj city)
چکیده یکی از مهمترین دغدغه های بزرگ جوامع بشری، از دیر باز تا کنون که ذهن پژوهشگران و متخصصان بهداشت روانی و اجتماعی و دولتها رابه خود مشغول داشته، مسأله ی بزهکاری می باشد. شناخت کامل پدیده ی بزهکاری و بزهکار، علل وعوامل سقوط یک انسان، چگونگی درمان وی و درنهایت پیشگیری ازبزهکاری ودریک کلام سالم سازی یک جامعه، رسالت عظیم، انسانی ومقدسی می باشد که با بررسی شخصیت مجرم یعنی[ انسانی که تحت شرای...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Iraqi Journal of Veterinary Medicine
سال: 2022
ISSN: ['1609-5693', '2410-7409']
DOI: https://doi.org/10.30539/ijvm.v46i2.1413